Distinct molecular subtypes of KRASG12C‐mutant lung adenocarcinoma: Insights into clinical outcomes, tumour microenvironments and therapeutic strategies

Abstract Background KRASG12C is the most common KRAS mutation in lung adenocarcinoma (LUAD), yet clinical responses to KRASG12C‐selective inhibitors (G12Ci) and immunotherapy remain variable. Methods Transcriptomic analysis of KRASG12C‐mutant LUAD was performed using machine learning algorithms to c...

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Auteurs principaux:	Haitang Yang, Anshun Zhu, Yongliang Niu, Wenyan Ma, Ke Xu, Yunxuan Jia, Weijiao Xu, Baicheng Zhao, Enshuo Zhang, Jiaying Jia, Shunqing Liang, Patrick Dorn, Gang Liu, Ren‐Wang Peng, Feng Yao
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2025-10-01
Collection:	Clinical and Translational Medicine
Sujets:	KRAS mutation lung adenocarcinoma molecular subtypes precision oncology treatment response tumour immune microenvironment
Accès en ligne:	https://doi.org/10.1002/ctm2.70490
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