Mechanistic multiphysics modeling reveals how blood pulsation drives CSF flow, pressure, and brain deformation under physiological and injection conditions
Abstract Intrathecal (IT) injection is an effective way to deliver drugs to the brain bypassing the blood-brain barrier (BBB). To evaluate and optimize IT drug delivery, it is necessary to understand the cerebrospinal fluid (CSF) dynamics in the central nervous system (CNS). In combination with expe...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2026-04-01
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| coleção: | Fluids and Barriers of the CNS |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s12987-026-00804-7 |
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