Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

We performed an X-ray crystallographic study of complexes of protein kinase PIM-1 with three inhibitors comprising an adenosine mimetic moiety, a linker, and a peptide-mimetic (<span style="font-variant: small-caps;">d</span>-Arg)₆ fragment. Guided by the structural models, simplified che...

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Autori principali:	Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-07-01
Serie:	Molecules
Soggetti:	protein X-ray crystallography co-crystal structure PIM kinases bisubstrate inhibitors fluorescent probes cellular uptake and localization
Accesso online:	https://www.mdpi.com/1420-3049/26/14/4353
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