Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening

Wilms tumors (WT) are characterized by variable contributions of blastemal, epithelial and stromal elements, reflecting their diverse cellular origins and genetic drivers. In vitro models remain rare, despite a growing need to better characterize tumor biology and evaluate new treatments. Using thre...

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主要な著者:	Lisa Götz, Jenny Wegert, Alireza Paikari, Silke Appenzeller, Sabrina Bausenwein, Christian Vokuhl, Taryn D. Treger, Jarno Drost, Christin Linderkamp, Dominik T. Schneider, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Nils Welter, Norbert Graf, Sam Behjati, Rhoikos Furtwängler, Manfred Gessler
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2025-02-01
シリーズ:	Translational Oncology
主題:	Wilms tumor Nephroblastoma Organoid culture Drug screening MYCN
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1936523324003899
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