Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity
Abstract The paracaspase MALT1 is essential for lymphocyte activation and also plays roles in non-immune cells and cancer. Its protease activity regulates immune signaling by cleaving specific substrates, making it a promising therapeutic target. However, broad inhibition of MALT1 protease activity...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Nature
2026-06-01
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| coleção: | EMBO Reports |
| Acesso em linha: | https://doi.org/10.1038/s44319-026-00814-4 |
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