Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

Background: Impaired alveolar macrophage (AM) efferocytosis may contribute to acute respiratory distress syndrome (ARDS) pathogenesis; however, studies are limited by the difficulty in obtaining primary AMs from patients with ARDS. Our objective was to determine whether an in vitro model of ARDS can...

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Autores principales:	Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Kylie B. R. Belchamber, Rowan S. Hardy, Michael A. Matthay, Babu Naidu, David R. Thickett
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-09-01
Colección:	Frontiers in Medicine
Materias:	ARDS (acute respiratory disease syndrome) alveolar macrophage (AM) efferocytosis BAL (bronchoalveolar lavage) Rac1 Rho-associated kinase (ROCK) inhibitor
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fmed.2021.737859/full
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