Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment

Abstract Genome editing by CRISPR-Cas9-nuclease is promising for gene therapy. However, safety concerns remain. Monitoring ON-target genotoxicity is essential, especially to assay megabasic rearrangements at the targeted locus. Here, we developed a combined single-cell resolution approach with DNA s...

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Principais autores:	Julian Boutin, Sabrina Fayet, Victor Marin, Camille Bergès, Maude Riandière, Jérôme Toutain, Isabelle Lamrissi-Garcia, Chloé Thibault, David Cappellen, Sandrine Dabernat, Arthur Poulet, Maëla Francillette, Nathalie Droin, Christelle Debeissat, Philippe Brunet de la Grange, François Moreau-Gaudry, Aurélie Bedel
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-68177-3
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