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A combinatorial code for splicing silencing: UAGG and GGGG motifs.

Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial control despite numerous sequences, distinct from splice sites, that have been shown to play roles in...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Kyoungha Han, Gene Yeo, Ping An, Christopher B Burge, Paula J Grabowski
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2005-05-01
Schriftenreihe:PLoS Biology
Online-Zugang:http://europepmc.org/articles/PMC1079783?pdf=render
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