Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Abstract Background Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT expression causes dysfunctional cortico-striatal (CS) transmission,...

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Principais autores:	Mandi E. Schmidt, Caodu Buren, James P. Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A. Raymond, Michael R. Hayden
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-06-01
Serija:	BMC Biology
Teme:	Huntington disease huntingtin synapse spine dendrite corticostriatal co-culture
Online dostop:	http://link.springer.com/article/10.1186/s12915-018-0526-3
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