RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

ABSTRACT Recent research demonstrated activation of the innate immune system in ALS models. This pathway can be activated by cGAS‐STING sensing of cytosolic DNA that accumulates as a result of chronic DNA damage and defective mitochondria, both of which was identified as pathology in FUS‐ALS. Theref...

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Bibliografske podrobnosti

Principais autores:	Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2026-03-01
Serija:	Advanced Science
Teme:	cGAS‐STING pathway double‐stranded RNA pathogen‐associated molecular patterns RIG‐I RIG‐I like receptors RNA‐sequencing
Online dostop:	https://doi.org/10.1002/advs.202417135
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