ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-β and constitutively active receptor induced gene expression

<p>Abstract</p> <p>Background</p> <p>TGF-β1 is an important angiogenic factor involved in the different aspects of angiogenesis and vessel maintenance. TGF-β signalling is mediated by the TβRII/ALK5 receptor complex activating the Smad2/Smad3 pathway. In endothelial cells TGF-β utilizes a second typ...

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Hlavní autoři:	Hafner Mathias, Kröner-Lux Gabriele, Dressman Holly K, Salway Fiona, Lux Andreas, Day Philip JR, Marchuk Douglas A, Garland John
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2006-04-01
Edice:	BMC Cardiovascular Disorders
On-line přístup:	http://www.biomedcentral.com/1471-2261/6/13
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