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Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

High-grade serous ovarian carcinoma (HGSOC) is one of the deadliest malignancies in female population and the cause of 70% of all ovarian cancer-related deaths. Among its hallmarks, the fluid accumulation in the peritoneal cavity, or ascites, is a peculiar pathological sign during late stages and in...

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Principais autores: Ivana Kurelac, Manuela Sollazzo, Monica De Luise, Francesca Nanetti, Laura Lanteri, Luigi D’Angelo, Beatrice Cavina, Simona Corrà, Stefano Miglietta, Sara Milioni, Elena Luppi, Luisa Iommarini, Stella Di Costanzo, Anna Maria Ricciardi, Sara Coluccelli, Thais Maloberti, Marco Grillini, Camelia Alexandra Coadă, Anna Myriam Perrone, Pierandrea De Iaco, Dario de Biase, Moira Ragazzi, Giuseppe Gasparre, Anna Maria Porcelli
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-02-01
Serier:Frontiers in Molecular Biosciences
Fag:
ovarian cancer
ascites
PAX8
TP53
cancer cell enrichment
Online adgang:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1537407/full
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