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L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

Abstract Background O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) is a highly sensitive PET tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-type amino-acid transporter 1 (LAT1). However, 30% of low- and 5% of high-grade gliomas do not present enhanced...

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Autori principali: Franziska J. Vettermann, Caroline Diekmann, Lorraine Weidner, Marcus Unterrainer, Bogdana Suchorska, Viktoria Ruf, Mario Dorostkar, Vera Wenter, Jochen Herms, Jörg-Christian Tonn, Peter Bartenstein, Markus J. Riemenschneider, Nathalie L. Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: SpringerOpen 2021-12-01
Serie:EJNMMI Research
Soggetti:
LAT1
FET PET
Glioma
Molecular imaging
Accesso online:https://doi.org/10.1186/s13550-021-00865-9
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