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Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

ABSTRACT Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) degenerate in Parkinson's disease (PD). Although pain is a common non‐motor symptom in PD, it remains unclear whether and how degeneration of SNc DA neurons contributes to hyperalgesia. In the present study, we revealed a...

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Wedi'i Gadw mewn:
Prif Awduron: Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wiley 2026-07-01
Cyfres:Advanced Science
Pynciau:
dopamine receptors
dopaminergic neurons
neuropathic pain
Parkinsonian pain
substantia nigra pars compacta
subthalamic nucleus
Mynediad Ar-lein:https://doi.org/10.1002/advs.202519913
Tagiau: Ychwanegu Tag
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