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Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth

Abstract Background Penfluridol (PF) is an FDA-approved antipsychotic drug that has recently been shown to have anticancer activity. However, the anticancer effects and underlying mechanisms of PF are not well-established in gallbladder cancer (GBC). Methods The anticancer efficacy of PF on GBC was...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jiahao Hu, Jiasheng Cao, Ren’an Jin, Bin Zhang, Win Topatana, Sarun Juengpanich, Shijie Li, Tian’en Chen, Ziyi Lu, Xiujun Cai, Mingyu Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-07-01
Schriftenreihe:Cell Communication and Signaling
Schlagworte:
Gallbladder cancer
Penfluridol
Apoptosis
Glycolysis
AMPK/PFKFB3
Online-Zugang:https://doi.org/10.1186/s12964-022-00882-8
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