Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

Abstract Background Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitio...

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Главные авторы:	Zainul Amiruddin Zakaria, Mohammad Hafiz Abdul Rahim, Mohd Hijaz Mohd Sani, Maizatul Hasyima Omar, Siew Mooi Ching, Arifah Abdul Kadir, Qamar Uddin Ahmed
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2019-04-01
Серии:	BMC Complementary and Alternative Medicine
Предметы:	Clinacanthus nutans; Acanthaceae Antinociceptive Mechanisms of action Opioid receptors NO-mediated/cGMP-independent pathway; phenolic compounds
Online-ссылка:	http://link.springer.com/article/10.1186/s12906-019-2486-8
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