Novel assays to assess the prevalence and neutralizing potential of anti-IdeS antibodies in healthy humans

BackgroundThe IgG-degrading enzyme IdeS (imlifidase) is a cysteine protease produced by Streptococcus pyogenes. It specifically hydrolyzes human IgG, cleaving the molecule to separate the F(ab’)2 fragment from the Fc region, thereby promoting IgG catabolism. The therapeutic form of IdeS (Idefirix®)...

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Main Authors:	Emna Hannachi, Amélia Trecco, Victoria Daventure, Sandrine Delignat, Perrine Bonilla, Maxime Lecerf, Olivier Thaunat, Jordan D. Dimitrov, Claire Deligne, Sébastien Lacroix-Desmazes
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Immunology
Subjects:	anti-IdeS antibodies IdeS Imlifidase neutralizing antibodies synthetic FRET substrate pre-existing immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1728855/full
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