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NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

Abstract Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and its association with p53. We utilized iCLIP to identify RNAs that directly bind to TIRR within cells, identifying the l...

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Principais autores: Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L. Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R. Poetsch, Maria Victoria Botuyan, Gaofeng Cui, Georges Mer, Jernej Ule, Pascal Drané, Dipanjan Chowdhury
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-09-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-024-52862-w
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