Key domains involved in the interaction and assembly of the HCMV terminase complex

Abstract Human cytomegalovirus (HCMV) causes life-threatening infections, particularly in immunocompromised patients. Letermovir targets the viral terminase complex (pUL56, pUL89, pUL51), essential for DNA packaging, but resistance mutations in pUL56 underline the need for new antiviral strategies....

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Autores principales:	C. Gourin, C. Lefèvre, T. Flores, A. Couvreux, S. Alain, G. Ligat, S. Hantz
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-11-01
Colección:	Scientific Reports
Materias:	Human cytomegalovirus Terminases pUL56 pUL89 Therapeutic targets
Acceso en línea:	https://doi.org/10.1038/s41598-025-28915-5
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