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TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations

BackgroundRecently, we could show that the co-mutations of KRAS + KEAP1, STK11 + KEAP1 and KRAS + STK11 + KEAP1 lead to a significantly shorter median overall survival (mOS) in patients with lung cancer across treatments by analyzing multiple dataset. TP53, a tumor suppressor gene, plays a crucial r...

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Principais autores: Armin Frille, Myriam Boeschen, Hubert Wirtz, Mathias Stiller, Hendrik Bläker, Maximilian von Laffert
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Oncology
Fag:
NSCLC
lung adenocarcinoma
KRAS
STK11
KEAP1
TP53
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1357583/full
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