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Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair

Schwann cell proliferation in peripheral nerve injury (PNI) enhances axonal regeneration compared to central nerve injury. However, even in PNI, long-term nerve damage without repair induces degeneration of neuromuscular junctions (NMJs), and muscle atrophy results in irreversible dysfunction. The p...

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Principais autores: Leyang Li, Hiroyuki Yokoyama, Hidetoshi Kaburagi, Takashi Hirai, Kunikazu Tsuji, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Atsushi Okawa
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2020-01-01
coleção:Neural Regeneration Research
Assuntos:
axon; nerve allograft; nerve regeneration; neurodegeneration; neuromuscular junction; peripheral nerve injury; schwann cell; skeletal muscle
Acesso em linha:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=4;spage=731;epage=738;aulast=Li
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