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Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics

We integrate evolutionary predictions based on the neutral theory of molecular evolution with protein dynamics to generate mechanistic insight into the molecular adaptations of the SARS-COV-2 spike (S) protein. With this approach, we first identified candidate adaptive polymorphisms (CAPs) of the SA...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Nicholas James Ose, Paul Campitelli, Tushar Modi, I Can Kazan, Sudhir Kumar, Sefika Banu Ozkan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2024-05-01
Rangatū:eLife
Ngā marau:
SARS-CoV-2
spike protein
evolution
dynamics
allostery
epistasis
Urunga tuihono:https://elifesciences.org/articles/92063
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