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Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration

Chaperone-mediated autophagy (CMA) contributes to selective degradation of individual soluble proteins in lysosomes. Unique to this type of autophagy is the fact that proteins reach the lysosomal lumen for degradation by directly crossing the lysosomal membrane, in contrast with the vesicle-mediated...

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Bibliografische gegevens
Hoofdauteurs: Hiroshi Koga, Ana Maria Cuervo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2011-07-01
Reeks:Neurobiology of Disease
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Online toegang:http://www.sciencedirect.com/science/article/pii/S0969996110002305
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