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Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents

Twelve novel neo-tanshinlactone–chalcone hybrid molecules were constructed through a versatile methodology involving the Horner–Wadsworth–Emmons (HWE) olefination of 4-formyl-2H-benzo [h]chromen-2-ones and phosphonic acid diethyl esters, as the key step, and evaluated for anticancer activity against...

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Principais autores: Nabil A. Alhakamy, Mohammad Saquib, Sanobar, Mohammad Faheem Khan, Waseem Ahmad Ansari, Deema O. Arif, Mohammad Irfan, Mohammad Imran Khan, Mohd Kamil Hussain
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2023.1231450/full
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