Dual-biomarkers encoding tumor-activatable minicircles with scaffold/matrix attachment region motif for sensitive and sustained blood and urine-based cancer detection

Abstract Background Liquid biopsy has been used for decades to detect cancer; however, endogenous biomarkers have limitations that can lead to misdiagnosis and hinder early detection. We previously developed tumor-activatable nonviral minicircles driven by a tumor-specific survivin promoter (pSURV),...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Hui-Yen Chuang, Wei-Chan Lin, Yu-Chieh Jill Kao, Chen-Hsuan Chiang, Carmel T. Chan, Aloma L. D’Souza, Sanjiv S. Gambhir, Sharon S. Hori
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Cancer Cell International
Assuntos:	Minicircle Cancer detection Liquid biopsy Scaffold/matrix attachment region (S/MAR) Synthetic biomarkers
Acesso em linha:	https://doi.org/10.1186/s12935-026-04241-2
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!