Endothelial glycocalyx perturbation in obstructive sleep apnea is associated with repetitive hypoxemia and immunothrombotic endothelial dysfunction

Abstract Background Obstructive sleep apnea (OSA) is associated with cardiovascular disease. The endothelial glycocalyx (eGCX) is a shear-sensitive intravascular barrier. The relevance of OSA and intermittent hypoxia (IH) for eGCX perturbation and cardiovascular disease in humans remains unclear. Me...

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Κύριοι συγγραφείς:	Martin Bernhard Müller, Tobias Kammerer, Humayun Khan, Annika Schmid, Simon Hirschberger, Max Hübner, Teresa K. Barth, Rea Mitsigiorgi, Clemens Stihl, Martin Holzer, Daniel Jira, Martin Patscheider, Bernhard G. Weiss, Christoph Andreas Reichel, Bernd Uhl
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2026-06-01
Σειρά:	Journal of Translational Medicine
Θέματα:	Endothelial glycocalyx Obstructive sleep apnea Intermittent hypoxia Hyaluronan Heparan sulfate Oxidative stress
Διαθέσιμο Online:	https://doi.org/10.1186/s12967-026-08409-2
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