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Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure

Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, UK. In a clinical collection of 519 A. fumigatus isolates, the frequency of itraconazole resistance was 5%, a sig...

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Principais autores: Susan J. Howard, Dasa Cerar, Michael J. Anderson, Ahmed Albarrag, Matthew C. Fisher, Alessandro C. Pasqualotto, Michel Laverdiere, Maiken C. Arendrup, David S. Perlin, David W. Denning
Formato: Artigo
Idioma:Inglês
Publicado em: Centers for Disease Control and Prevention 2009-07-01
coleção:Emerging Infectious Diseases
Assuntos:
Aspergillus fumigatus
azoles
antifungal drug resistance
sterol 14-alpha demethylase CYP51A
Aspergillus
population genetics
Acesso em linha:https://wwwnc.cdc.gov/eid/article/15/7/09-0043_article
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