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Mitochondrial Genome Study Identifies Association Between Primary Open-Angle Glaucoma and Variants in MT-CYB, MT-ND4 Genes and Haplogroups

Background and purpose: Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by death of retinal ganglion cells and atrophy of the optic nerve head. The susceptibility of the optic nerve to damage has been shown to be mediated by mitochondrial dysfunction. In this study, we aimed...

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Principais autores: Valeria Lo Faro, Ilja M. Nolte, Jacoline B. Ten Brink, Harold Snieder, Nomdo M. Jansonius, Arthur A. Bergen, Lifelines Cohort Study
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Genetics
Assuntos:
mitochondrial polymorphism
mitochondrial haplogroup
primary open-angle glaucoma (POAG)
MT-CYB
MT-ND4
haplogroup K
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2021.781189/full
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