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A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

Antagonizing TNF-α signaling attenuates chronic inflammatory disease, but is associated with adverse effects on the cardiovascular system. Therefore the impact of TNF-α on basal control of redox signaling events needs to be understand in more depth. This is particularly important for the Keap1/Nrf2...

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Principais autores: Gobinath Shanmugam, Madhusudhanan Narasimhan, Ramasamy Sakthivel, Rajesh Kumar R, Christopher Davidson, Sethu Palaniappan, William W. Claycomb, John R. Hoidal, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016-10-01
Series:Redox Biology
Assuntos:
Nrf2 signaling
TNF-α
Antioxidants
Oxidative stress
Apoptosis
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2213231716300507
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