Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for m...

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Detalhes bibliográficos

Principais autores:	Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S. B. Wolff, Eystein S. Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Adrian Hayday, Pärt Peterson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-08-01
coleção:	Frontiers in Immunology
Assuntos:	autoimmune regulator autoantibodies immune tolerance thymus autoantigen
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00976/full
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