The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus. Here we test the hypothesis that pathological bursts in dopamine-deprived basal ganglia...

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Principais autores:	Rachida eAmmari, Bernard eBioulac, Liliana eGarcia, Constance eHammond
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2011-06-01
סדרה:	Frontiers in Systems Neuroscience
נושאים:	Basal Ganglia Subthalamic Nucleus Parkinson burst firing basal ganglia slice high frequency stimulation
גישה מקוונת:	http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00043/full
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