Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly

The stimulation of autophagy or lysosomes has been considered therapeutic for neurodegenerative disorders because the accumulation of misfolded proteins is commonly observed in the brains of individuals with these diseases. Although zinc is known to play critical roles in the functions of lysosomes...

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Detalhes bibliográficos

Principais autores:	Ki-Ryeong Kim, Sang Eun Park, Ji-Ye Hong, Jae-Young Koh, Dong-Hyung Cho, Jung Jin Hwang, Yang-Hee Kim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-09-01
Colecção:	Frontiers in Cellular Neuroscience
Assuntos:	zinc lysosome autophagy TFEB cathepsin B cathepsin D
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2022.895750/full
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