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The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes

Biomechanical (over-)stimulation, in addition to inflammatory and fibrotic stimuli, severely impacts the anterior cruciate ligament (ACL) biology, contributing to the overall chronic nature of desmopathy. A major challenge has been the lack of representative two-dimensional (2D) in vitro models mimi...

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Principais autores: Johannes Heidenberger, Raphael Hangel, Eva I. Reihs, Jonathan Strauss, Petra Liskova, Jürgen Alphonsus, Cornelia Brunner, Kevin Döring, Iris Gerner, Florien Jenner, Reinhard Windhager, Stefan Toegel, Mario Rothbauer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-12-01
coleção:Frontiers in Bioengineering and Biotechnology
Assuntos:
mechanical loading
ligamentocytes
inflammation
fibrosis
in vitro modelling
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1469238/full
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