Chimeric RXFP1 and RXFP2 receptors highlight the similar mechanism of activation utilizing their N-terminal low density lipoprotein class A modules

Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low density lipoprotein type A (LDLa) module which is necessary for receptor activation. The current hypothesis suggests that upon ligand binding the LDLa module interacts with t...

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Detalhes bibliográficos

Principais autores:	Shoni eBruell, Roy CK Kong, Emma June Petrie, Brad L Hoare, John D Wade, Daniel J Scott, Paul Raymond Gooley, Ross eBathgate
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2013-11-01
coleção:	Frontiers in Endocrinology
Assuntos:	Relaxin signalling GPCR INSL3 RXFP1 RXFP2
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00171/full
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