Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum

Abstract Background Androstenedione (AD) is an important steroid medicine intermediate that is obtained via the degradation of phytosterols by mycobacteria. The production process of AD is mainly the degradation of the phytosterol aliphatic side chain, which is accompanied by the production of propi...

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Autores principales:	Yang Zhang, Xiuling Zhou, Xuemei Wang, Lu Wang, Menglei Xia, Jianmei Luo, Yanbing Shen, Min Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2020-01-01
Colección:	Microbial Cell Factories
Materias:	Mycobacterium neoaurum Androstenedione Methylcitrate cycle Transcriptional regulator Nitrogen level
Acceso en línea:	https://doi.org/10.1186/s12934-020-1285-8
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