Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles

Abstract The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the axon is associated with neurodegener...

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Auteurs principaux:	Phillip A. Kohl, Chaeyeon Song, Bretton J. Fletcher, Rebecca L. Best, Christine Tchounwou, Ximena Garcia Arceo, Peter J. Chung, Herbert P. Miller, Leslie Wilson, Myung Chul Choi, Youli Li, Stuart C. Feinstein, Cyrus R. Safinya
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2024-03-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-024-46438-x
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