Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

N-Methyl-d-aspartate (NMDA) receptors play critical roles in central nervous system function and are involved in variety of brain disorders. We previously developed a series of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid glycine site agonists with pronounced variation in activity among NMDA r...

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Detaylı Bibliyografya
Asıl Yazarlar:	Fabao Zhao, Georgios Mazis, Feng Yi, James S. Lotti, Michael S. Layeux, Eric P. Schultz, Lennart Bunch, Kasper B. Hansen, Rasmus P. Clausen
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2022-11-01
Seri Bilgileri:	Frontiers in Chemistry
Konular:	ionotropic glutamate receptors ligand-gated ion channel two-electrode voltage-clamp electrophysiology co-agonist subtype selectivity
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fchem.2022.1008233/full
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Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

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