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Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

I tiakina i:
Ngā kaituhi matua: Sumin Jo, Shipra Das, Alan Williams, Anne-Sophie Chretien, Thomas Pagliardini, Aude Le Roy, Jorge Postigo Fernandez, Diane Le Clerre, Billal Jahangiri, Isabelle Chion-Sotinel, Sandra Rozlan, Emilie Dessez, Agnes Gouble, Mathilde Dusséaux, Roman Galetto, Aymeric Duclert, Emanuela Marcenaro, Raynier Devillier, Daniel Olive, Philippe Duchateau, Laurent Poirot, Julien Valton
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2022-06-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-022-30896-2
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