Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit

Background: Diabetic retinopathy (DR) remains one of the most common complications of diabetes despite great efforts to uncover its underlying mechanisms. The pathogenesis of DR is characterized by the deterioration of the neurovascular unit (NVU), showing damage of vascular cells, activation of gli...

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Hlavní autoři:	Yixin Wang, Rachana Eshwaran, Susanne C. Beck, Hans-Peter Hammes, Thomas Wieland, Yuxi Feng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-07-01
Edice:	Molecular Metabolism
Témata:	Hexosamine biosynthetic pathway Retinal neurovascular unit Hyperglycemia O-GlcNAc Endothelial cell Pericyte
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2212877823000704
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