PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Abstract Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors, and FBXL4 mutations result in mitochondrial dis...

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Bibliografiske detaljer

Principais autores:	Giang Thanh Nguyen-Dien, Brendan Townsend, Prajakta Gosavi Kulkarni, Keri-Lyn Kozul, Soo Siang Ooi, Denaye N Eldershaw, Saroja Weeratunga, Meihan Liu, Mathew JK Jones, S Sean Millard, Dominic CH Ng, Michele Pagano, Alexis Bonfim-Melo, Tobias Schneider, David Komander, Michael Lazarou, Brett M Collins, Julia K Pagan
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer Nature 2024-07-01
Serier:	EMBO Reports
Fag:	Mitophagy FBXL4 BNIP3 NIX PPTC7
Online adgang:	https://doi.org/10.1038/s44319-024-00181-y
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