The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

ABSTRACT Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclea...

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Principais autores:	Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2018-10-01
coleção:	mSphere
Assuntos:	alphavirus host-pathogen interactions innate immunity interferon-stimulated gene virus-host interactions
Acesso em linha:	https://journals.asm.org/doi/10.1128/mSphere.00209-18
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