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LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

BackgroundCorneal neovascularization (CNV) is a sight-threatening condition that necessitates epigenetic control. The role of lysine-specific demethylase 1 (LSD1) in CNV remains unclear, despite its established significance in tumor angiogenesis regulation.MethodsAn alkali burn-induced CNV mouse mod...

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Principais autores: Qian Deng, Yuelan Gao, Yujin Wang, Jiewen Mao, Yulin Yan, Zixian Yang, Yuyu Cong, Yanning Yang, Shanshan Wan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-07-01
coleção:Frontiers in Pharmacology
Assuntos:
alkali burn
corneal neovascularization
lysine-specific demethylase 1
tranylcypromine hydrochloride
HIF-1α
ferroptosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2024.1411513/full
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