Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations

Both the accumulation of Amyloid-β (Aβ) in plaques and phosphorylation of Tau protein (p-Tau) in neurofibrillary tangles have been identified as two major symptomatic features of Alzheimer's disease (AD). Despite of critical role of Aβ and p-Tau in AD progress, the interconnection of signalling path...

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Detalhes bibliográficos

Principais autores:	Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Park
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-05-01
coleção:	Redox Biology
Assuntos:	ACL Alzheimer disease Aβ NADK Superoxide p-Tyr42 RhoA
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231719316015
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