Multi-omics characterization of developing forebrain organoids unravels the dynamic molecular events of Rett syndrome pathogenesis

Abstract Background Rett Syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Despite its monogenic nature, the molecular events contributing to RTT pathogenesis are not fully elucidated. Methods We applied a multi-omics approach to comprehensively analyse...

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Auteurs principaux:	Jarno Koetsier, Nasim Bahram Sangani, Ana Rita Gomes, Maria Margarida Diogo, Tiago G. Fernandes, Freek G. Bouwman, Edwin C. M. Mariman, Mehrnaz Ghazvini, Leon J. Schurgers, Joost Gribnau, Leopold M.G. Curfs, Chris P. Reutelingsperger, Lars M.T. Eijssen
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2026-04-01
Collection:	Journal of Neurodevelopmental Disorders
Sujets:	Rett syndrome MeCP2 Brain organoids Transcriptomics Proteomics lncRNAs
Accès en ligne:	https://doi.org/10.1186/s11689-026-09699-9
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