Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication. Here, we show that Nsp5 binds and cleaves human tRNA methyltransferase 1 (TRMT1), a host enzyme required for a prevalent post-transcriptiona...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kejia Zhang, Patrick Eldin, Jessica H Ciesla, Laurence Briant, Jenna M Lentini, Jillian Ramos, Justin Cobb, Joshua Munger, Dragony Fu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2024-05-01
Schriftenreihe:	eLife
Schlagworte:	SARS-CoV-2 coronavirus tRNA TRMT1 Nsp5 main protease
Online-Zugang:	https://elifesciences.org/articles/90316
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