Improved Treatment Outcomes by Using Patient Specific Drug Combinations in Mammalian Target of Rapamycin Activated Advanced Metastatic Cancers

Background: Activation of the mTOR signaling pathway is ubiquitous in cancers and a favourable therapeutic target. However, presently approved mTOR inhibitor monotherapies have modest benefits in labeled indications while poor outcomes have been reported for mTOR inhibitor monotherapy when administe...

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Hlavní autoři:	Timothy Crook, Darshana Patil, Andrew Gaya, Nicholas Plowman, Sewanti Limaye, Anantbhushan Ranade, Amit Bhatt, Raymond Page, Dadasaheb Akolkar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-04-01
Edice:	Frontiers in Pharmacology
Témata:	encyclopedic tumor analysis ETA mTOR PIK3CA PI3K Akt
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2021.631135/full
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