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Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy

Human β-cardiac myosin exists in an ON-state where both myosin heads are accessible for interaction with actin, and an OFF-state where the heads are folded back onto their own coiled-coil tail, interacting with each other via an interacting-heads motif (IHM). Hypertrophic cardiomyopathy (HCM) mutati...

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Principais autores: James A Spudich, Neha Nandwani, Julien Robert-Paganin, Anne Houdusse, Kathleen M Ruppel
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2024-08-01
Serier:The EMBO Journal
Fag:
β-Cardiac Myosin
Hypertrophic Cardiomyopathy
Interacting Heads Motif
Super-relaxed State
Unifying Hypothesis
Online adgang:https://doi.org/10.1038/s44318-024-00199-x
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