Tyrosine phosphatase Shp2 accelerated the progression of dilated cardiomyopathy via upregulating NF-κB/Src/FAK signaling induced ROS and mitophagy

Abstract The purpose of this study was to investigate whether tyrosine phosphatase Shp2 can promote the progression of dilated cardiomyopathy by upregulating intracellular oxidative stress and subsequently promoting mitophagy. Macrophage-specific Shp2 knockout mice were cultured and a dilated cardio...

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Hauptverfasser:	Jingxia Hao, Hua Wang, Bo Li, Jingshi Chen, Wenlu Wang, Yingxue Wang, Yingqian Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-08-01
Schriftenreihe:	Scientific Reports
Schlagworte:	BMMs SHP-2 Dilated cardiomyopathy Oxidative stress Mitophagy
Online-Zugang:	https://doi.org/10.1038/s41598-025-04375-9
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