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CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing

Sensory hair cell death caused by the ototoxic side effects of many clinically used drugs leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are widely used and well-known for their ototoxicity, but the molecular mechanisms of aminoglycoside-induced hair cell death...

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Detalhes bibliográficos
Principais autores: Litao Tao, Neil Segil
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-10-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1013383/full
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