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NK cells beat T cells at early breast cancer control

Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in...

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Principais autores: Aitziber Buque, Norma Bloy, Giulia Petroni, Guido Kroemer, Lorenzo Galluzzi
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2020-01-01
Serier:OncoImmunology
Fag:
hormonotherapy
immune checkpoint blockers
nicotinamide
pd-1
type i interferon
tumor microenvironment
Online adgang:http://dx.doi.org/10.1080/2162402X.2020.1806010
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